Toxic hepatis during ketoconazole treatment.
نویسندگان
چکیده
منابع مشابه
Cholesterol metabolism during ketoconazole treatment in man.
Ketoconazole, an antifungal antibiotic, inhibits cholesterol synthesis by blocking demethylation of lanosterol. Effects of this inhibition were studied on serum cholesterol, lipoproteins and cholesterol precursors, biliary lipid composition, and fecal steroid elimination in five patients with prostate cancer treated with large doses of ketoconazole. The serum level of total cholesterol fell by ...
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Benign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracr...
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Laparoscopic cholecystectomy is the surgical procedure of choice for symptomatic gallstones. The incidence of bile duct injury following laparoscopic cholecystectomy is around 0.62% and, when vascular injuries also occur, the surgeon is faced with is a serious complication1. Morbidity and mortality increase drastically when bileduct and vascular injuries occur simultaneously and a successful ou...
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Minimally invasive surgery in children has evolved to the extent that complex procedures can be performed with safety, with comparable outcomes to open surgery and with the advantages of minimal scarring and less pain. In this article, we describe the latest laparoscopic techniques used at Juntendo University Hospital in Japan, for treating conditions affecting the porta hepatis, focusing on bi...
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BACKGROUND Hypercortisolemia is frequently observed in major depression but its pathophysiologic significance is unknown. In patients in whom hypercortisolism contributes to depressive symptomatology, antiglucocorticoid agents should have antidepressant effects. METHODS Twenty medication-free depressed patients (eight of whom were hypercortisolemic and twelve of whom were not) received either...
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ژورنال
عنوان ژورنال: BMJ
سال: 1981
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.283.6295.825